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別驚訝，這是真的！現(xiàn)有研究表明，除了飲食和鍛煉，肥胖由肥胖基因決定。 加州大學洛杉磯分校研究發(fā)現(xiàn)，相同情況下你的體重增加了而別人卻沒有，這可能是因為你們的基因存在差異。 飲食和鍛煉仍是影響肥胖的最大因素。研究人員認為，基因在很大程度上決定了一個高脂肪飲食的人其體重增加的程度。 在本項研究中，研究員們研究了100只小鼠的基因，觀察這些小鼠在8周時間內(nèi)正常飲食情況，隨后又觀察這些小鼠在8周時間內(nèi)高脂肪高糖的飲食情況。即使小鼠吃同樣的食物，它們的體重也存在很大的差異。有的高脂肪飲食老鼠體內(nèi)脂肪百分比沒有變化，有的老鼠體內(nèi)脂肪百分比卻增加了600%。 這些差異很大程度上是遺傳導致的?？茖W家識別并對比了老鼠基因中11個與肥胖和脂肪增加相關的區(qū)域，其中有幾個區(qū)域跟人類的肥胖基因重疊。 首席研究員 Jake Lusis博士表明：“我們都見過那些吃很多但是不長胖的人。調(diào)查結果完全符合這一現(xiàn)象，基因?qū)ζ溆蟹浅４蟮挠绊懥Α薄?br/> Lusis博士希望未來某一天，能研發(fā)出針對肥胖基因的藥物和治療方法。雖然這樣的個性化醫(yī)療至少需要5到10年的時間，醫(yī)生可以用成像技術使病人的代謝或者產(chǎn)生熱量的褐色脂肪變得直觀形象。 已有研究表明，肥胖有較高的遺傳可能性。在后續(xù)的研究中，研究人員希望能夠識別更多的“肥胖基因”并且測試這些基因是如何導致體重增加。 英文原文 “Fat Genes” Determine Obesity, UCLA Study Says, In Addition To Diet And Exercise A new University of California Los Angeles study says you probably gained weight, and he didn't, because of a difference in your genes. 'If we understand how genetic factors influenced so much of the population to become obese, we could potentially reverse it with more research,' Dr. Parks said In the study, UCLA researchers gave more than 100 genetic strains of mice a normal diet for eight weeks, followed by a high-fat, high-sugar diet for another eight weeks. Even though the mice were eating the exact same diets, their weight gain varied greatly. The high-fat diet caused no change in body-fat percentage for some mice while others' body fat percentages increased by a whopping 600 percent. Those differences were largely attributed to genetics. The scientists identified and compared 11 genetic regions associated with obesity and fat gain in the mice, several of which overlap with genes linked to obesity in humans. The genetic differences translated into some mice being naturally more active and some being more effective at generating heat and thereby burning calories. 'We've all seen those people who eat a lot and don't gain weight. Our results are entirely consistent with that notion,' principal investigator Dr. Jake Lusis。 It isn’t just all about how much we eat. Genes had a huge effect.' 'If people consume a high-fat diet, the response will be predominantly determined by genetics,' Dr. Lusis said. 'But whether you choose to eat a high-fat diet in the first place is largely environmental.'While there have been numerous studies that have shown that obesity has high heritability, this is the first comprehensive study to examine whether response to a high-fat diet is genetic. Still, the researchers emphasized that environmental factors such as diet and exercise are also important to weight gain. Dr. Brian Parks, study co-author and a postdoctoral researcher at the Geffen School of Medicine, told HuffPost that he hopes this and future research will lead to designing drugs and treatments that specifically target 'fat genes.' And while that kind of personalized medicine is at least five to 10 years away, doctors soon be able to use imaging to visualize a patient's metabolism or 'brown fat,' which generates heat, Dr. Lusis said. In follow-up studies, the researchers hope to identify more 'fat genes' and test the identified genes to understand how they're contributing to weight gain. The scientists also hope to understand the genetics of losing 。 |
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來自： 中國健康食品網(wǎng) > 《待分》
