關(guān)鍵詞：A20 IKKβ AlphaFold  甲基酯酶 GmPMI1R  血管緊張素轉(zhuǎn)換酶2 程序性細(xì)胞死亡1 程序性細(xì)胞死亡配體1 軟骨酸性蛋白-1 (CRTAC1) 納米抗體 法瑞西單抗（Faricimab） 特瑞普利單抗 貝伐珠單抗 愛潑斯坦-巴爾病毒（EBV） 納武利尤單抗（Nivolumab）

①Fish & Shellfish Immunology：Black carp A20 inhibits interferon signaling through de-ubiquitinating IKKβ

A20通過去泛素化和降低IKKβ的磷酸化來抑制IKKβ介導(dǎo)的抗病毒活性的新機(jī)制

DOI：10.1016/j.fsi.2024.109781

②Molecular Plant：AlphaFold-guided redesign of a plant pectin methylesterase inhibitor for broad-spectrum disease resistance

AlphaFold設(shè)計(jì)的一種特異性抑制病原體果膠甲基酯酶的修飾蛋白GmPMI1R增強(qiáng)植物病原體的抗性

DOI：10.1016/j.molp.2024.07.008

③iScience：Activation of limbal epithelial proliferation is partly controlled by the ACE2-LCN2 pathway

血管緊張素轉(zhuǎn)換酶2 (ACE2)的下調(diào)通過TGFA/EGFR/LCN2途徑促進(jìn)角膜緣上皮細(xì)胞的增殖

DOI：10.1016/j.isci.2024.110534

④Unlocking immunotherapy targets: programmed death 1 and its ligand and their correlation with tumour grade in feline injection site sarcoma

程序性細(xì)胞死亡1 (PD-1)和程序性細(xì)胞死亡配體1 (PD-L1)的免疫組織化學(xué)表達(dá)為貓注射部位肉瘤(FISSs)的免疫治療提供潛在靶點(diǎn)

DOI：10.1016/j.jcpa.2024.06.006

⑤Journal of Molecular Biology：CRTAC1 has a compact β-propeller–TTR core stabilized by potassium ions

軟骨酸性蛋白-1 (CRTAC1) 具有由鉀離子穩(wěn)定的緊湊β-螺旋槳-TTR核心結(jié)構(gòu)

DOI：10.1016/j.jmb.2024.168712

⑥International Journal of Biological Macromolecules：Structural insights into the binding of nanobodies to the staphylococcal enterotoxin B

B型葡萄球菌腸毒素(SEB)與納米抗體結(jié)合的晶體結(jié)構(gòu)為開發(fā)治療SEB誘導(dǎo)疾病的納米抗體提供了結(jié)構(gòu)和治療策略

DOI：10.1016/j.ijbiomac.2024.133957

⑦重磅雙特異性抗體療法法瑞西單抗（Faricimab）治療糖尿病性黃斑水腫（DME）長(zhǎng)期有效

⑧抗PD-1抗體特瑞普利單抗的新適應(yīng)癥上市申請(qǐng)已獲得受理，聯(lián)合貝伐珠單抗用于不可切除或轉(zhuǎn)移性肝細(xì)胞癌（HCC）

⑨EBV特異性T細(xì)胞免疫療法Tabelecleucel（tab-cel）的BLA獲FDA授予優(yōu)先審評(píng)資格，用于愛潑斯坦-巴爾病毒（EBV）陽性的移植后淋巴增殖性疾?。≒TLD）

⑩PD-1單抗納武利尤單抗（Nivolumab）新適應(yīng)癥上市申請(qǐng)獲受理，推測(cè)用于肝細(xì)胞癌