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Anemarrhena asphodeloides modulates gut microbiota and restores pancreatic function in diabetic rats 知母調(diào)節(jié)糖尿病大鼠的腸道菌群并恢復(fù)其胰腺功能 10.1016/j.biopha.2020.110954 11-29, Article Abstract & Authors:展開(kāi) Abstract:收起
Anemarrhena asphodeloides is an herb widely used to treat symptoms associated with diabetes in traditional Chinese medicine. However, its key components and metabolites have low bioavailability and poor host absorption. To clarify the anti-diabetic mechanism of A. asphodeloides extract (AAE), we examined the anti-diabetic effects of AAE in rats with diabetes induced by a high-fat diet and streptozotocin. Faeces levels of the main components and metabolites of AAE were significantly higher than levels in plasma, which indicated that gut microbiota might play important roles in its anti-diabetic effect. Microbiological studies showed that unabsorbed components increased the diversity of the gut microbiota, enriched potentially beneficial bacteria, and suppressed potentially harmful bacteria. In vitro studies showed that AAE promoted the proliferation of Blautia coccoides, a bacterium with positive implication for diabetes, in a dose-dependent manner. AAE also promoted pancreatic cell regeneration and restored the function of pancreatic islet cells via peroxiredoxin 4 overexpression. Overall, these results suggest that AAE alleviates diabetes via modulating gut microbiota and protein expression.
First Authors:
Dong Yan,Pengcheng Fan,Wenlong Sun,Qianzhi Ding Correspondence Authors:
Yuesheng Dong,Ping Xu,Liyan Yu,Baiping Ma All Authors:
Dong Yan,Pengcheng Fan,Wenlong Sun,Qianzhi Ding,Wei Zheng,Weidi Xiao,Bowei Zhang,Tao Zhang,Tao Zhang,Jiahui Shi,Xiaojuan Chen,Peiru Chen,Jie Zhang,Ying Hao,Xinguang Sun,Xu Pang,Yuesheng Dong,Ping Xu,Liyan Yu,Baiping Ma
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