LOCUS NP_006538 579 aa linear PRI 26-NOV-2018 DEFINITION insulin-like growth factor 2 mRNA-binding protein 3 [Homo sapiens]. ACCESSION NP_006538 VERSION NP_006538.2 DBSOURCE REFSEQ: accession NM_006547.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 579) AUTHORS Kim HY, Ha Thi HT and Hong S. TITLE IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor JOURNAL Cancer Lett. 415, 30-39 (2018) PUBMED 29217458 REMARK GeneRIF: Data show that insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis represents a double-negative feedback loop and serves as a new potential therapeutic target for the treatment of Triple-negative breast cancer (TNBC). REFERENCE 2 (residues 1 to 579) AUTHORS Elagib KE, Lu CH, Mosoyan G, Khalil S, Zasadzinska E, Foltz DR, Balogh P, Gru AA, Fuchs DA, Rimsza LM, Verhoeyen E, Sanso M, Fisher RP, Iancu-Rubin C and Goldfarb AN. TITLE Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition JOURNAL J. Clin. Invest. 127 (6), 2365-2377 (2017) PUBMED 28481226 REMARK GeneRIF: IGF2BP3 as a human ontogenic master switch that restricts megakaryocyte development by modulating a lineage-specific P-TEFb activation mechanism. REFERENCE 3 (residues 1 to 579) AUTHORS Wei Q, Zhou H, Zhong L, Shi L, Liu J, Yang Q and Zhao T. TITLE IMP3 expression in biopsy specimens as a diagnostic biomarker for colorectal cancer JOURNAL Hum. Pathol. 64, 137-144 (2017) PUBMED 28412210 REMARK GeneRIF: IMP3 is a reliable marker for the diagnosis of colorectal cancer in endoscopic biopsies REFERENCE 4 (residues 1 to 579) AUTHORS Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, Zhang B, Wu WK, Cheng AS, Yu J, To KF and Kang W. TITLE IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis JOURNAL Mol. Cancer 16 (1), 77 (2017) PUBMED 28399871 REMARK GeneRIF: We compressively revealed the oncogenic role of IGF2BP3 in gastric tumorigenesis and confirmed its activation is partly due to the silence of miR-34a. Our findings identified useful prognostic biomarker and provided clinical translational potential. Publication Status: Online-Only REFERENCE 5 (residues 1 to 579) AUTHORS Shi R, Yu X, Wang Y, Sun J, Sun Q, Xia W, Dong G, Wang A, Gao Z, Jiang F and Xu L. TITLE Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer JOURNAL Tumour Biol. 39 (4), 1010428317695928 (2017) PUBMED 28381175 REMARK GeneRIF: IGF2BP3 might play the most important role in tumor aggressiveness and prognosis in lung adenocarcinoma. REFERENCE 6 (residues 1 to 579) AUTHORS Yaniv K and Yisraeli JK. TITLE The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis JOURNAL Gene 287 (1-2), 49-54 (2002) PUBMED 11992722 REMARK Review article REFERENCE 7 (residues 1 to 579) AUTHORS Zhang JY, Chan EK, Peng XX, Lu M, Wang X, Mueller F and Tan EM. TITLE Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies JOURNAL Clin. Immunol. 100 (2), 149-156 (2001) PUBMED 11465943 REFERENCE 8 (residues 1 to 579) AUTHORS Mueller-Pillasch F, Pohl B, Wilda M, Lacher U, Beil M, Wallrapp C, Hameister H, Knochel W, Adler G and Gress TM. TITLE Expression of the highly conserved RNA binding protein KOC in embryogenesis JOURNAL Mech. Dev. 88 (1), 95-99 (1999) PUBMED 10525192 REFERENCE 9 (residues 1 to 579) AUTHORS Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM and Nielsen FC. TITLE A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development JOURNAL Mol. Cell. Biol. 19 (2), 1262-1270 (1999) PUBMED 9891060 REFERENCE 10 (residues 1 to 579) AUTHORS Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G and Gress TM. TITLE Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein JOURNAL Oncogene 14 (22), 2729-2733 (1997) PUBMED 9178771 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079780.6, AC021876.5 and AC005082.3. On May 16, 2003 this sequence version replaced NP_006538.1. Summary: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF117108.1, U76705.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..579 /organism="Homo sapiens" /db_xref="taxon:Protein 1..579 /product="insulin-like growth factor 2 mRNA-binding protein 3" /note="cancer/testis antigen 98; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; VICKZ family member 3; IGF2 mRNA-binding protein 3" /calculated_mol_wt=63574 Region 1..77 /region_name="RRM1_IGF2BP3" /note="RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3); cd12627" /db_xref="CDD:Region 81..156 /region_name="RRM2_IGF2BP3" /note="RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3); cd12630" /db_xref="CDD:Site 184 /site_type="other" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000244|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (O00425.2)" Region 198..262 /region_name="KH_1" /note="KH domain; pfam00013" /db_xref="CDD:Site order(205,207..209,211..215,218..219,222..223,228..231) /site_type="other" /note="nucleic acid binding region [nucleotide binding]" /db_xref="CDD:Site 212..215 /site_type="other" /note="G-X-X-G motif" /db_xref="CDD:Region 279..344 /region_name="KH-I" /note="K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; cd00105" /db_xref="CDD:Site order(286,288..290,292..296,299..300,303..304,309..312) /site_type="other" /note="nucleic acid binding region [nucleotide binding]" /db_xref="CDD:Site 293..296 /site_type="other" /note="G-X-X-G motif" /db_xref="CDD:Region 407..471 /region_name="KH_1" /note="KH domain; pfam00013" /db_xref="CDD:Site order(415,417..419,421..425,428..429,432..433,436..439) /site_type="other" /note="nucleic acid binding region [nucleotide binding]" /db_xref="CDD:Site 422..425 /site_type="other" /note="G-X-X-G motif" /db_xref="CDD:Region 492..555 /region_name="KH_1" /note="KH domain; pfam00013" /db_xref="CDD:Site order(497,499..501,503..507,510..511,514..515,520..523) /site_type="other" /note="nucleic acid binding region [nucleotide binding]" /db_xref="CDD:Site 504..507 /site_type="other" /note="G-X-X-G motif" /db_xref="CDD:Site 528 /site_type="other" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine. {ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163}; propagated from UniProtKB/Swiss-Prot (O00425.2)" CDS 1..579 /gene="IGF2BP3" /gene_synonym="CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3" /coded_by="NM_006547.3:382..2121" /db_xref="CCDS:HGNC:28868" /db_xref="MIM: 1 mnklyignls enaapsdles ifkdakipvs gpflvktgya fvdcpdeswa lkaiealsgk 61 ielhgkpiev ehsvpkrqri rklqirnipp hlqwevldsl lvqygvvesc eqvntdseta 121 vvnvtysskd qarqaldkln gfqlenftlk vayipdemaa qqnplqqprg rrglgqrgss 181 rqgspgsvsk qkpcdlplrl lvptqfvgai igkegatirn itkqtqskid vhrkenagaa 241 eksitilstp egtsaacksi leimhkeaqd ikfteeiplk ilahnnfvgr ligkegrnlk 301 kieqdtdtki tisplqeltl ynpertitvk gnvetcakae eeimkkires yendiasmnl 361 qahlipglnl nalglfppts gmppptsgpp samtppypqf eqsetetvhl fipalsvgai 421 igkqgqhikq lsrfagasik iapaeapdak vrmviitgpp eaqfkaqgri ygkikeenfv 481 spkeevklea hirvpsfaag rvigkggktv nelqnlssae vvvprdqtpd endqvvvkit 541 ghfyacqvaq rkiqeiltqv kqhqqqkalq sgppqsrrk // |
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