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As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring. 隨著男性精子生產(chǎn)能力降低，擁有Y染色體精子的比例亦減少。因此，男性的生殖潛力可能預(yù)測他獲得男性后代的能力。 In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. 近年來，調(diào)查研究者注意到許多工業(yè)化國家出現(xiàn)男性出生比例下降的趨勢。 While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. 盡管男性承載著決定性別的染色體（Y染色體--譯注），承擔(dān)受精或流產(chǎn)的女性伴侶也可能發(fā)揮改變性別比例的角色。 We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm. 通過直接檢查男性精子決定性別的染色體，我們試圖確定一位男性后代的性別比例（第一代）。 We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH). 我們對我們男性不育臨床數(shù)據(jù)庫中所有做過精液熒光原位雜交（FISH）的男性數(shù)據(jù)進(jìn)行了審查。 Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios (Y chromosomes/total chromosomes). Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters. 對不育患者的人口統(tǒng)計資料與精液參數(shù)進(jìn)行了記錄。采用卡方分析用來做比較性別比（Y染色體/總?cè)旧w）。采用多變量邏輯回歸來預(yù)測考慮了人口統(tǒng)計資料與精液參數(shù)后的擁有Y染色體精子的幾率。 A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6%; P=0.02). 總共184位男性進(jìn)行了精液熒光原位雜交（FISH）。對185位男性整個群體而言，擁有Y染色體精子的比例為51.5%。然而，精液中精子數(shù)量少于500萬個活動精子的男性，他們擁有的Y染色體精子的比例（50.8%）統(tǒng)計意義低于精子數(shù)量更高的男性（51.6%; P=0.02）。 After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01). 多變量調(diào)整后揭示，精子濃度更高、總活動性精子數(shù)量與精液量統(tǒng)計意義增高擁有Y染色體精子的機會（P<0.01）。 As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring. 結(jié)論：隨著男性精子生產(chǎn)能力降低，擁有Y染色體精子的比例亦減少。因此，男性的生殖潛力可能預(yù)測他獲得男性后代的能力。 Eisenberg ML et al., Sperm counts and sperm sex ratio in male infertility patients,Asian J Androl. 2012 Sep;14(5):683-6. Epub 2012 Jul 30. Eisenberg ML et al.，男性不育患者中的精子數(shù)量與精子性別比，亞洲男科雜志，2012年9月；14(5):683-6.。上網(wǎng)發(fā)布：2012年7月30日 http://www./abstracts/sperm-counts-and-sperm-sex-ratio-male-in-infertility-patients Department of Urology, Stanford University School of Medicine, Stanford, USA. 美國斯坦福大學(xué)醫(yī)學(xué)院泌尿系
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